GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs13191362 | 1 | rs66529337 | chr6:163005662 | PACRG | chr6:163148164-163736523:+ | 0.44 | 6.89 | 1.77E-11 | Body mass index |
| THCA | cis | rs2292096 | 1 | rs66530019 | chr1:200813692 | DDX59 | chr1:200610119-200639126:- | -0.26 | -3.96 | 8.59E-5 | Epilepsy |
| THCA | cis | rs2292096 | 1 | rs66530521 | chr1:200782949 | DDX59 | chr1:200610119-200639126:- | -0.27 | -4.08 | 5.33E-5 | Epilepsy |
| THCA | cis | rs13424612 | 1 | rs66534347 | chr2:240899346 | NDUFA10 | chr2:240900158-240964798:- | 0.3 | 8.47 | 3.03E-16 | Odorant perception (isobutyraldehyde) |
| THCA | cis | rs13191362 | 1 | rs66534429 | chr6:163003322 | PACRG | chr6:163148164-163736523:+ | 0.44 | 6.89 | 1.77E-11 | Body mass index |
| THCA | cis | rs11825709 | 1 | rs66538341 | chr11:93762532 | HEPHL1 | chr11:93754378-93847374:+ | 0.43 | 3.43 | 0.000648 | Obesity-related traits |
| THCA | cis | rs4357530 | 1 | rs6656450 | chr1:151089602 | BNIPL | chr1:151009029-151020076:+ | -0.18 | -3.68 | 0.000258 | Body mass index |
| THCA | cis | rs12748152 | 1 | rs6656815 | chr1:27292462 | ZDHHC18 | chr1:27153201-27182207:+ | 0.61 | 6.61 | 9.99E-11 | HDL cholesterol;Triglycerides;LDL cholesterol |
| THCA | cis | rs2275426 | 1 | rs6656992 | chr1:46333068 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -10.1 | 7.22E-22 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6656992 | chr1:46333068 | GPBP1L1 | chr1:46092978-46152302:- | 0.16 | 4.05 | 5.93E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6656992 | chr1:46333068 | MMACHC | chr1:45965856-45976737:+ | -0.2 | -4.4 | 1.34E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6656992 | chr1:46333068 | MUTYH | chr1:45794915-45806142:- | 0.31 | 8.53 | 1.99E-16 | Body mass index |
| THCA | cis | rs1075232 | 1 | rs66581165 | chr15:31743767 | FAM7A2 | chr15:30864758-30892900:+ | -0.42 | -3.78 | 0.000174 | Survival in colorectal cancer (non-distant metastatic) |
| THCA | cis | rs9782955 | 1 | rs6658406 | chr1:236029475 | LYST | chr1:235824345-236046940:- | -0.32 | -9.71 | 1.88E-20 | Systemic lupus erythematosus |
| THCA | cis | rs2292096 | 1 | rs6658596 | chr1:200748921 | DDX59 | chr1:200610119-200639126:- | 0.25 | 3.85 | 0.000135 | Epilepsy |